Anal Cancer

Although rare, anal cancer is becoming more prevalent in the United States and many other developing countries. The condition develops in the tissues of the anus, which is a short tube that connects the lower part of the large intestine, known as the rectum, to the outside of the body. The anus allows the controlled disposal of body waste during bowel movements.

Like cervical cancer, the principal cause of anal cancer is human papillomavirus (HPV), a common virus that causes changes in the skin. Anal HPV infection is most commonly acquired through anal intercourse, but it can also be acquired from other genital areas that are infected, particularly from the vulva in women, or from the penis in men. Fingers and toys can probably lead to anal HPV infection as well.

Research suggests that sexually active individuals, both men and women, may be at risk for HPV. The good news is that only a fraction of people with anal HPV infection will develop a lasting case of anal intraepithelial neoplasia (AIN) — a precursor to anal cancer — and even fewer will develop anal cancer.

 

Patients with invasive anal cancer experience a wide variety of symptoms, but at the earliest stage of cancer, patients often have no symptoms. The most common symptoms include:

  • Pain or tenderness in the area around the anus, which can be constant or occur only with bowel movements or receptive sex
  • Bleeding with bowel movements or following sex that is different from normal
  • Lump or hard area on the outside of the anal area that appears to be increasing in size
  • Itching or discharge from the anus
  • Pain or a sense of fullness and constant need to go to the bathroom, or both, which may occur as tumors grow and begin to invade the sphincter muscle

If you are at risk of anal cancer or are experiencing symptoms, it is important to contact your doctor and be examined promptly. If cancer is detected, an early diagnosis will help improve outcomes and smaller tumors can be treated more effectively with fewer side effects.

 

Reviewed by health care specialists at UCSF Medical Center.